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 See Mike Eat His Words

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Mr. Mordax
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PostSubject: See Mike Eat His Words   1/14/2009, 1:05 pm

See Mike.
See Mike eat his words.
Eat your words, Mike, eat your words.

Identification of allergens in the venom of the common striped scorpion wrote:
Background: The common striped scorpion, Centruroides vittatus, is endemic to the southwestern United States and causes thousands of human stings annually. Immediate hypersensitivity reactions to C vittatus venom have been reported.

Objectives: To identify specific IgE in 11 patients with immediate hypersensitivity to C vittatus and to characterize the allergens present in the venom.

Methods: Skin testing to dialyzed, filtered venom was performed in 5 patients. Immunoglobulin E immunoblots to whole milked venom was accomplished with serum samples from 8 patients, Enzymatic properties of whole venom were also determined.

Results: C vittatus venom was found to contain 150 μg/μL of protein. Four of 5 patients tested had positive skin test reactions to the purified venom extract, with no late reactions. In all 8 patients, sodium dodecyl sulfate-polyacrylamide gel electrophoresis demonstrated multiple proteins, 9 of which were identified as allergens on IgE immunoblots, ranging in size from 30 to 170 kD. Enzymatic activity was found to include phospholipase A, alkaline phosphatase, esterase, esterase lipase, and acid phosphatase.

Conclusions: C vittatus envenomation may result in immediate hypersensitivity reactions in susceptible individuals. Venom specific IgE can be identified by using skin tests and IgE immunoblots. The allergens identified in these patients had molecular weights distinct from those of known scorpion neurotoxins. A safe and effective skin testing extract can be prepared from dialyzed pure venom and may lead to the widespread ability to diagnose C vittatus venom allergy.

I'm still saying I was half-right -- the functional groups in the venom weren't what caused the reaction. There's something else in there that was doing it.

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scorpion111
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PostSubject: Re: See Mike Eat His Words   1/14/2009, 1:08 pm

If I knew what the hell you were talking about I would laugh.

but venom will still laugh.
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Mr. Mordax
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PostSubject: Re: See Mike Eat His Words   1/14/2009, 1:13 pm

It means that it's possible to have an allergy to scorpion venom, and perform a medical test to determine this.

However, I still haven't seen a reliable report of anaphylaxis from scorpion venom (or even an unreliable report, for that matter). If anyone finds that, I'll really have to eat my words.

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SeanCasey
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PostSubject: Re: See Mike Eat His Words   1/14/2009, 2:03 pm

Read the section under 'Toxic dose"
It has a reference to a footnote (2) that is not available in the online exceprt.

Read the first paragraph

Not very conclusive, but I figured it would add to the discussion.
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LadyRiotControl
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PostSubject: Re: See Mike Eat His Words   1/14/2009, 5:25 pm

well you learn something new every day Smile
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~Abyss~
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PostSubject: Re: See Mike Eat His Words   1/14/2009, 8:00 pm

what flavor are those words mike? They look good and I'm hungry
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